Computational Modeling of C-Terminal Tails to Predict the Calcium-Dependent Secretion of Endoplasmic Reticulum Resident Proteins
The lumen of the endoplasmic reticulum (ER) has resident proteins that are critical to perform the various tasks of the ER such as protein maturation and lipid metabolism.These ER resident proteins typically have a carboxy-terminal ER retention/retrieval sequence (ERS).The canonical ERS Pregnancy Test that promotes ER retrieval is Lys-Asp-Glu-Leu (